What is Histidine and how does it help skin?

Histidine is an amino acid that is a key component of the skin's natural moisturizing factor (NMF). It helps to keep the skin hydrated, supports its protective barrier, and offers antioxidant benefits.

Is Histidine suitable for sensitive skin?

Yes, as a natural component of the skin, histidine is generally well-tolerated and can help support the skin's barrier, making it beneficial for sensitive skin types.

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Histidine

Also known as: L-Histidine

Histidine is an essential amino acid that plays a crucial role in the skin's natural moisturizing factor (NMF). It helps to maintain skin hydration and supports the skin's barrier function. It also has antioxidant properties, protecting the skin from environmental damage.

Amino acid

BenefitGood 2.8 / 4

Hydration i3 / 4

Whether the ingredient helps increase the skin’s water content — humectants that attract water, ingredients that reduce water loss, or ones that make skin feel less dry.

Soothing i1.5 / 4

Whether it can calm the skin — linked to less redness, irritation, discomfort, or visible reactivity.

Uv protection i0.8 / 4

Whether it provides direct protection against UV radiation.

RiskVery low 0 / 4

Rated by SpottyLabs' ingredient methodology, independent of brands.

What it helps with

enhances skin hydration
supports skin barrier
provides antioxidant protection

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Products with Histidine

Eucerin

UreaRepair PLUS 10% Urea Lotion

4.6/ 521/7/4

Pantene

Pro-V Intensive Repair Conditioner

4.5/ 56/5/8

The Ordinary

Natural Moisturizing Factors + HA

4.4/ 529/11/6

Olaplex

Bond Maintenance Clarifying Shampoo

4.1/ 516/18/9

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Frequently asked questions

What is Histidine and how does it help skin?: Histidine is an amino acid that is a key component of the skin's natural moisturizing factor (NMF). It helps to keep the skin hydrated, supports its protective barrier, and offers antioxidant benefits.
Is Histidine suitable for sensitive skin?: Yes, as a natural component of the skin, histidine is generally well-tolerated and can help support the skin's barrier, making it beneficial for sensitive skin types.