What is sh-Polypeptide-9?

sh-Polypeptide-9 is a synthetic version of Vascular Endothelial Growth Factor (VEGF), a human protein involved in the formation of blood vessels. It is produced biotechnologically for cosmetic use.

How does sh-Polypeptide-9 benefit the skin?

It is believed to enhance skin's microcirculation, which can improve nutrient delivery and oxygenation to skin cells, supporting overall skin health, regeneration, and a more radiant appearance.

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sh-Polypeptide-9

sh-Polypeptide-9 is a synthetic protein that mimics human Vascular Endothelial Growth Factor (VEGF). This growth factor is crucial for the formation of new blood vessels. In skincare, it is included for its potential to support skin health and regeneration by improving microcirculation.

NoneGrowth factorVeganEvidence: Medium

BenefitGood 2.5 / 4

Anti aging i2.5 / 4

Whether it can help visible signs of aging — fine lines, wrinkles, loss of firmness, or photoaging.

Texture i2 / 4

Whether it can improve smoothness and surface texture — roughness, flaking, clogged pores, or unevenness. Exfoliating acids, retinoids, and smoothing moisturizers may score here.

RiskLow 0.5 / 4

Systemic exposure i0.5 / 4

Whether it has meaningful potential to be absorbed into the body at levels that may matter biologically. Most cosmetic ingredients score low unless there is known concern or high exposure.

Rated by SpottyLabs' ingredient methodology, independent of brands.

What it helps with

Supports skin regeneration
Promotes microcirculation
Aids in skin repair

Things to watch

Potential for systemic absorption, though generally considered low risk in topical applications.

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Products with sh-Polypeptide-9

Drunk Elephant

Protini Powerpeptide Resurf Serum

4.7/ 544/27/6

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Frequently asked questions

What is sh-Polypeptide-9?: sh-Polypeptide-9 is a synthetic version of Vascular Endothelial Growth Factor (VEGF), a human protein involved in the formation of blood vessels. It is produced biotechnologically for cosmetic use.
How does sh-Polypeptide-9 benefit the skin?: It is believed to enhance skin's microcirculation, which can improve nutrient delivery and oxygenation to skin cells, supporting overall skin health, regeneration, and a more radiant appearance.