Does this peptide contain nicotine?

No, it is a purified recombinant protein expressed in plant leaves and contains no nicotine.

What are the main benefits of this peptide?

It mimics natural growth factor signaling to support skin firmness, reduce wrinkle depth, and encourage hair follicle health.

Home › Ingredients › Nicotiana Benthamiana Octapeptide-30 sh-Oligopeptide-2

Nicotiana Benthamiana Octapeptide-30 sh-Oligopeptide-2

Also known as: Plant-derived IGF-1 mimic, Bioengineered sh-Oligopeptide-2

This plant-expressed fusion peptide is bioengineered in Nicotiana benthamiana to mimic insulin-like growth factor signaling. It supports cellular renewal, collagen synthesis, and hair follicle vitality. It is well tolerated by most skin types, carrying minimal risk of irritation.

Bioengineered peptideVegan

BenefitGood 2.5 / 4

Anti aging i2.5 / 4

Whether it can help visible signs of aging — fine lines, wrinkles, loss of firmness, or photoaging.

Texture i1.8 / 4

Whether it can improve smoothness and surface texture — roughness, flaking, clogged pores, or unevenness. Exfoliating acids, retinoids, and smoothing moisturizers may score here.

RiskLow 0.5 / 4

Sensitization i0.5 / 4

Risk of allergic contact dermatitis or immune-based reactions. Fragrance allergens, preservatives, botanicals, and some dyes may score here.

Irritation i0.5 / 4

Risk of short-term irritation — stinging, burning, dryness, redness, or discomfort. Common for strong actives, acids, retinoids, fragrances, and harsh surfactants.

Rated by SpottyLabs' ingredient methodology, independent of brands.

What it helps with

Promotes skin firmness and elasticity
Supports cellular renewal
Nourishes hair follicles

Things to watch

Low risk of mild skin irritation
Potential for sensitization in reactive individuals

Pairs well with

Niacinamide — Soothes skin and reinforces the moisture barrier alongside peptide activity.
Hyaluronic Acid — Provides hydration that complements cellular renewal.

Be careful combining with

Aha — Low pH chemical exfoliants may destabilize or hydrolyze peptides when layered together.

See how this matches your skin

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Products with Nicotiana Benthamiana Octapeptide-30 sh-Oligopeptide-2

CÉCRED

Restoring Lash & Brow Builder

4.3/ 514/9/3

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Frequently asked questions

Does this peptide contain nicotine?: No, it is a purified recombinant protein expressed in plant leaves and contains no nicotine.
What are the main benefits of this peptide?: It mimics natural growth factor signaling to support skin firmness, reduce wrinkle depth, and encourage hair follicle health.