Is this peptide suitable for sensitive skin?

Yes, it is generally very gentle and well tolerated, though sensitive skin always benefits from a patch test.

How does it help aging skin?

It mimics vascular signaling factors to support nutrient flow, promoting a refreshed and revitalized complexion.

Home › Ingredients › Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9

Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9

Also known as: Plant-derived VEGF mimic, sh-Polypeptide-9 fusion peptide

This bioengineered peptide is produced in Nicotiana benthamiana host plants to mimic vascular endothelial growth factor. It helps revitalize tired skin, support microcirculation, and boost overall skin glow. It is gentle on the skin barrier and carries very low risk of irritation.

Bioengineered peptideVegan

BenefitModerate 2.4 / 4

Anti aging i2.4 / 4

Whether it can help visible signs of aging — fine lines, wrinkles, loss of firmness, or photoaging.

Soothing i1.5 / 4

Whether it can calm the skin — linked to less redness, irritation, discomfort, or visible reactivity.

RiskLow 0.5 / 4

Sensitization i0.5 / 4

Risk of allergic contact dermatitis or immune-based reactions. Fragrance allergens, preservatives, botanicals, and some dyes may score here.

Irritation i0.5 / 4

Risk of short-term irritation — stinging, burning, dryness, redness, or discomfort. Common for strong actives, acids, retinoids, fragrances, and harsh surfactants.

Rated by SpottyLabs' ingredient methodology, independent of brands.

What it helps with

Enhances skin vitality and radiance
Supports skin microcirculation
Improves early signs of aging

Things to watch

Low risk of mild topical irritation
Possible sensitization in sensitive individuals

Pairs well with

Niacinamide — Enhances microcirculation support and barrier comfort.
Centella Asiatica Extract — Calms skin and works synergistically to promote skin recovery.

Be careful combining with

Aha — Acidic environments can compromise peptide stability and reduce efficacy.

See how this matches your skin

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Products with Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9

CÉCRED

Restoring Lash & Brow Builder

4.3/ 514/9/3

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Frequently asked questions

Is this peptide suitable for sensitive skin?: Yes, it is generally very gentle and well tolerated, though sensitive skin always benefits from a patch test.
How does it help aging skin?: It mimics vascular signaling factors to support nutrient flow, promoting a refreshed and revitalized complexion.