What makes plant-produced peptides special?

Using plants like Nicotiana benthamiana allows sustainable, high-purity production of complex human-mimetic growth factor peptides without animal inputs.

Can this peptide replace retinol?

While it targets collagen production with less irritation than retinol, it works through different biological pathways and can complement a retinoid routine.

Home › Ingredients › Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-86

Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-86

Also known as: Plant-derived TGF-beta mimic, sh-Polypeptide-86 peptide

This advanced peptide is synthesized via plant biotechnology in Nicotiana benthamiana to mimic transforming growth factor activity. It signals fibroblasts to produce key structural proteins like collagen, significantly enhancing skin firmness and elasticity. It delivers concentrated anti-aging benefits while maintaining high cutaneous tolerance.

Bioengineered peptideVegan

BenefitGood 2.6 / 4

Anti aging i2.6 / 4

Whether it can help visible signs of aging — fine lines, wrinkles, loss of firmness, or photoaging.

Texture i1.7 / 4

Whether it can improve smoothness and surface texture — roughness, flaking, clogged pores, or unevenness. Exfoliating acids, retinoids, and smoothing moisturizers may score here.

RiskLow 0.5 / 4

Sensitization i0.5 / 4

Risk of allergic contact dermatitis or immune-based reactions. Fragrance allergens, preservatives, botanicals, and some dyes may score here.

Irritation i0.5 / 4

Risk of short-term irritation — stinging, burning, dryness, redness, or discomfort. Common for strong actives, acids, retinoids, fragrances, and harsh surfactants.

Rated by SpottyLabs' ingredient methodology, independent of brands.

What it helps with

Stimulates collagen synthesis
Improves skin firmness and elasticity
Smooths deep lines and wrinkles

Things to watch

Minimal potential for skin irritation
Rare risk of allergic contact response

Pairs well with

Retinoid — Can be alternated to support structural collagen remodeling through complementary pathways.
Ceramides — Maintains barrier hydration while the peptide supports dermal structure.

Be careful combining with

Aha — High acidity may alter peptide structure and degrade signaling activity.

See how this matches your skin

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Products with Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-86

CÉCRED

Restoring Lash & Brow Builder

4.3/ 514/9/3

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Frequently asked questions

What makes plant-produced peptides special?: Using plants like Nicotiana benthamiana allows sustainable, high-purity production of complex human-mimetic growth factor peptides without animal inputs.
Can this peptide replace retinol?: While it targets collagen production with less irritation than retinol, it works through different biological pathways and can complement a retinoid routine.