Can niacinamide be used with vitamin C?

Yes, niacinamide and vitamin C can be used together. Older research suggested a potential interaction, but modern formulations and studies show they are compatible and can offer complementary benefits.

What percentage of niacinamide is effective?

Studies show that niacinamide is effective at concentrations ranging from 2% to 10%. Higher concentrations may offer more pronounced benefits but can also increase the chance of mild irritation for some individuals.

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Niacinamide

Niacinamide is a form of vitamin B3 that offers multiple benefits for the skin. It helps improve skin barrier function, reduce inflammation, and minimize the appearance of pores. It is a versatile ingredient suitable for various skin concerns.

NiacinamideVitaminVeganEvidence: High

BenefitStrong 3.8 / 4

Barrier support

Soothing

Pigmentation

Acne

Texture

Oil control

RiskLow 0.5 / 4

Irritation

Sensitization

Rated by SpottyLabs' ingredient methodology, independent of brands.

What it helps with

Improves skin barrier
Reduces inflammation
Minimizes pores
Evens skin tone

Things to watch

Mild flushing (rare)
Initial irritation (rare)

Pairs well with

Retinoid — Niacinamide can help mitigate potential irritation and dryness associated with retinoids, improving tolerability.
Vitamin C — Niacinamide and Vitamin C can be used together effectively, with Niacinamide potentially enhancing antioxidant benefits and reducing irritation.

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Products with Niacinamide

Niacinamide 10 + TXA 3 Serum

Score 4.8 / 5

Relief Sun: Rice + Probiotics SPF50+ PA++++

Score 4.7 / 5

Niacinamide 10% + Zinc 1%

Score 3.9 / 5

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Frequently asked questions

Can niacinamide be used with vitamin C?: Yes, niacinamide and vitamin C can be used together. Older research suggested a potential interaction, but modern formulations and studies show they are compatible and can offer complementary benefits.
What percentage of niacinamide is effective?: Studies show that niacinamide is effective at concentrations ranging from 2% to 10%. Higher concentrations may offer more pronounced benefits but can also increase the chance of mild irritation for some individuals.